Anticancer and antibacterial potential of robust Ruthenium(II) arene complexes regulated by choice of α-diimine and halide ligands

Several complexes of general formula [Ru(halide)(η 6 - p -cymene)(α-diimine)] + , in the form nitrate, triflate and hexafluorophosphate salts, including a newly synthesized iodide compound, were investigated as potential anticancer drugs bactericides . NMR UV–Vis studies evidenced remarkable stability water cell culture medium. In general, displayed strong cytotoxicity against A2780 A549 cancer lines with IC 50 values low micromolar range, one complex ( RUCYN ) emerged most promising one, significant selectivity compared to non-cancerous HEK293 line. A variable affinity for BSA DNA binding was ascertained by spectrophotometry/fluorimetry, circular dichroism electrophoresis viscometry The performance appears associated enhanced internalization, favored two cyclohexyl substituents, rather than specific interaction evaluated biomolecules. chloride/iodide replacement, case, led increased cellular uptake at expense selectivity, tuned towards intercalation Complexes or valproate bioactive fragment exhibited best antimicrobial profiles. Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begoña Garcia, Fabio MarchettiWithin cationic Ru II -arene complexes, appropriate choice halide substituents on α -diimine allows fine modulation cytotoxicity, biomolecules antibacterial activity, (nitrate salt) candidate. • Cytotoxicity mechanistic Ru(II) arene diazadiene ligands. Outstanding provided introduction groups. Profound consequences activity replacement.